trending Market Intelligence /marketintelligence/en/news-insights/trending/eRoiSjEE695o0P67rXfXow2 content
Log in to other products

Login to Market Intelligence Platform

 /


Looking for more?

Contact Us

Request a Demo

You're one step closer to unlocking our suite of comprehensive and robust tools.

Fill out the form so we can connect you to the right person.

If your company has a current subscription with S&P Global Market Intelligence, you can register as a new user for access to the platform(s) covered by your license at Market Intelligence platform or S&P Capital IQ.

  • First Name*
  • Last Name*
  • Business Email *
  • Phone *
  • Company Name *
  • City *
  • We generated a verification code for you

  • Enter verification Code here*

* Required

In This List

US drug pricing watchdog to examine AbbVie's upadacitinib in arthritis

Gauging Supply Chain Risk In Volatile Times

S&P Global Market Intelligence

Cannabis: Hashing Out a Budding Industry

Segment

IFRS 9 Impairment How It Impacts Your Corporation And How We Can Help

The Market Intelligence Platform


US drug pricing watchdog to examine AbbVie's upadacitinib in arthritis

AbbVie Inc.'s rheumatoid arthritis prospect upadacitinib will be the subject of an updated review by the Institute for Clinical and Economic Review examining the cost-effectiveness of 11 arthritis drugs, including the company's bestseller Humira.

The drug pricing watchdog, known as ICER, found in a 2017 assessment that eight of the 11 drugs were more cost-effective for moderate to severe rheumatoid arthritis than Humira.

Upadacitinib, which was found to be superior to Humira in a head-to-head study, received the U.S. Food and Drug Administration's priority review designation in February, which brings the agency's expected decision date to the third quarter.

The 11 immunotherapy drugs from the previous report are AbbVie's Humira, UCB SA's Cimzia and Amgen Inc.'s Enbrel; Johnson & Johnson's Simponi and Remicade; Bristol-Myers Squibb Co.'s Orencia and Roche Holding AG's Actemra; Roche and Biogen Inc.'s Rituxan; Sanofi and Regeneron Pharmaceuticals Inc.'s Kevzara; Eli Lilly and Co.'s Olumiant and Pfizer Inc.'s Xeljanz.

ICER determines the cost-effectiveness of a drug by examining disease burden for patients using a quality-adjusted life year. The organization determined in its previous review of the rheumatoid arthritis drugs that they required discounts of 69% to 29% to be considered cost-effective.

Humira had sales of $19.94 billion in 2018, but biosimilar encroachment and the lack of a succession plan for the blockbuster drug have applied pressure to AbbVie's strategy, as indicated by executives on the company's most recent earnings call. The company is looking to upadacitinib to bolster revenue as Humira faces increasing competition.