trending Market Intelligence /marketintelligence/en/news-insights/trending/BZg4aQt_-fUDijOw4fYDFA2 content
Log in to other products

Login to Market Intelligence Platform

 /


Looking for more?

Contact Us

Request a Demo

You're one step closer to unlocking our suite of comprehensive and robust tools.

Fill out the form so we can connect you to the right person.

If your company has a current subscription with S&P Global Market Intelligence, you can register as a new user for access to the platform(s) covered by your license at Market Intelligence platform or S&P Capital IQ.

  • First Name*
  • Last Name*
  • Business Email *
  • Phone *
  • Company Name *
  • City *
  • We generated a verification code for you

  • Enter verification Code here*

* Required

Thank you for your interest in S&P Global Market Intelligence! We noticed you've identified yourself as a student. Through existing partnerships with academic institutions around the globe, it's likely you already have access to our resources. Please contact your professors, library, or administrative staff to receive your student login.

At this time we are unable to offer free trials or product demonstrations directly to students. If you discover that our solutions are not available to you, we encourage you to advocate at your university for a best-in-class learning experience that will help you long after you've completed your degree. We apologize for any inconvenience this may cause.

In This List

Jazz Pharmaceuticals drug lowers sleep disorder symptoms in late-stage study

COVID-19 Pandemic Likely To Cause US Telemedicine Boom

Gauging Supply Chain Risk In Volatile Times

S&P Global Market Intelligence

Cannabis: Hashing Out a Budding Industry

Segment

IFRS 9 Impairment How It Impacts Your Corporation And How We Can Help


Jazz Pharmaceuticals drug lowers sleep disorder symptoms in late-stage study

Jazz Pharmaceuticals PLC said a late-stage study of JZP-258 met its main goal of reducing attacks of physical collapse among patients with narcolepsy, a sleep disorder.

Narcolepsy is a chronic neurological disorder characterized by excessive daytime sleepiness. Cataplexy, which occurs in about 70% narcolepsy patients, refers to a sudden loss of muscle tone with retained consciousness. It is usually triggered by strong emotions, such as laughter, surprise or anger and can lead to sporadic partial attacks to frequent complete collapse.

The phase 3 study involved 201 patients and compared JZP-258 with placebo in treating cataplexy in adult patients with narcolepsy. The patients included those previously treated with Xyrem, or having no treatment with Xyrem, as well as those with or without other anti-cataplectic treatments.

Xyrem, or sodium oxybate, is a top-selling drug of Dublin-based Jazz Pharmaceuticals, which is also used to treat narcolepsy and cataplexy. However, JZP-258 has 92% less sodium than Xyrem.

The study demonstrated that JZP-258 showed a statistically significant difference in reducing the weekly number of cataplexy attacks while placebo led to a worsening of attacks.

JZP-258 also met its secondary goal of showing a statistically significant difference in the measure of daytime sleepiness compared to placebo. The drug's safety profile was found to be similar to Xyrem. However, two patients reported serious side effects linked by the investigator to JZP-258.

Narcolepsy patients need a new, low-sodium oxybate formulation as excessive consumption of sodium is linked with an increased risk of stroke, cardiovascular disease and other adverse outcomes, said Michael Thorpy, a director at Montefiore Health System in New York.

The company plans to discuss results with the U.S. Food and Drug Administration in order to proceed with a new drug application for JZP-258.