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Same-Day Analysis

Swedish Human Pharmaceutical Sales Grow 4% Y/Y to US$3.3 bil., Generics Underperform Overall Market

Published: 18 February 2009
Sales of branded prescription drugs have fuelled the Swedish pharmaceutical market's growth in 2008 as sales of generics, parallel imports and over-the-counter medicines have comparatively stalled.

IHS Global Insight Perspective

 

Significance

The Swedish pharmaceutical market for human use has grown 4% year-on-year (y/y) in 2008 to 28.8 billion Swedish kronor (US$3.3 billion). By volume the market has grown 3% y/y to nearly 6 billion defined daily doses sold. Prices of prescription drugs for human use have fallen by 2.03% y/y over the period.

Implications

Market growth was fuelled by sales of antineoplastic and immunomodulating agents as well as central nervous system drugs. While prescription drugs account for 90% of the total market, generics and parallel imports have seen their market penetration stall in 2008, with each retaining a market share by value identical to that held in 2007.

Outlook

The Swedish pharmaceutical market is expected to keep growing on the back of increased demand for newer therapies. Rational use of medicines will remain at the top of the political agenda and steps could be taken to reignite growth in the generic market. With the liberalisation of the distribution market due for 1 July, the downward pressure on pharmaceutical prices could intensify in 2009.

Swedish sales of pharmaceuticals for human use have grown 4% year-on-year (y/y) to 28.82 billion Swedish kronor (US$3.29 billion) in 2008, according to fresh figures from the Swedish Association of the Pharmaceutical Industry (Lif). In the meantime, sales of generics have grown at half the overall market rate (2% y/y) to 4.12 billion kronor while sales of parallel imported medicines were nearly flat (+0.3% y/y) at 3.25 billion kronor. Parallel imports account for 11.1% of the Swedish pharmaceutical market at wholesale prices. In 2008, per capita spending on pharmaceuticals was up 3.3% y/y to 3,727 kronor.

In 2008, prescription drugs accounted for 90% of the total market for human use while over-the-counter (OTC) medicines accounted for 9% of that market, according to Lif. Sales of OTC medicines, inclusive of veterinary sales, amounted to 2.46 billion kronor in 2008, down from 2.61 billion kronor in 2007. Lif estimates that veterinary sales of OTC medicines amounted to about 0.4% (10 million kronor) of the total OTC sales in 2008.

Market growth was fuelled by sales of antineoplastics and immunosuppressant agents, and central nervous system (CNS) drugs whose sales reached 5.3 and 5.1 billion kronor respectively, corresponding to a respective market share of 18.6% and 17.9%. Alimentary tract and metabolism treatments were next in line with sales growing 9.8% y/y to 2.8 billion kronor.

Swedish Human Pharmaceutical Sales by Leading Therapeutic Categories, 2008

ATC Therapeutic Groups

Sales (mil. kronor, Wholesale Prices)

Market Share (%)

Alimentary Tract and Metabolism (A)

2,835

9.8

Blood and Blood-Forming Organs (B)

2,600

9.0

Cardiovascular System (C)

2,686

9.3

Dermatologicals (D)

651

2.3

Genito-Urinary and Sex Hormones (G)

1,416

4.9

Hormones excluding Sex Hormones and Insulin (H)

740

2.6

General Anti-Infectives for Systemic Use (J)

2,764

9.6

Antineoplastics and Immunosuppressant Drugs (L)

5,349

18.6

Musculoskeletal System (M)

1,020

3.5

Central Nervous System (N)

5,153

17.9

Antiparasitic Agents , Various (P + V)

634

2.2

Respiratory System (R)

2,303

8.0

Sensory Organs (S)

605

2.1

Source: Swedish Association of the Pharmaceutical Industry, 2009

By best-selling drugs, Sweden's top-10 remains in line with 2007, although 2008 marks the entry of breast cancer drug Herceptin (trastuzumab; Roche, Switzerland) in the league table. In line with other Western European countries, disease-modifying antirheumatic drugs (DMARDs) featured high on the list of best-selling medicines by turnover with Enbrel (etanercept; Amgen, U.S.), Remicade (infliximab; Schering-Plough, U.S.) and Humira (adalimumab; Abbott Laboratories, U.S.) leading the way with respective sales of 676, 450 and 417 million kronor. Sales of the country's top-15 medicines amounted to 17% of the total market by value in 2008.

Swedish Best-Selling Drugs by Turnover, 2008

Pharmaceutical

Manufacturer

Therapeutic Class

2008 Sales (mil. kronor, Wholesale Prices)

Enbrel

Wyeth

Immunosuppressive

676

Symbicort

AstraZeneca

Respiratory

486

Remicade

Johnson & Johnson

Anti-inflammatory

450

Humira

Abbott Laboratories

Anti-inflammatory

417

Lipitor

Pfizer

Cardiovascular

355

Atacand

Takeda

Cardiovascular

350

Cozaar

Merck

Cardiovascular

332

Zyprexa

Eli Lilly

Mental Health

309

Effexor

Wyeth

Mental Health

282

Herceptin

Roche

Oncology

252

Source: Swedish Association of the Pharmaceutical Industry, 2009

In 2008, prices of primary care pharmaceuticals for human use fell by an average of 1.68% y/y. More specifically, prices of prescription drugs fell by 2.03% y/y while prices of OTC medicines rose by 1.87% y/y.

Pharmaceutical Price Evolution in Swedish Human Primary Care Market, 2008

 

Price Evolution at Wholesale Price (%)

All Ambulatory Pharmaceuticals for Human Use

-1.68

Prescription Drugs for Human Use

-2.03

OTC for Human Use

1.87

Source: Swedish Association of the Pharmaceutical Industry, 2009

Outlook and Implications

The Swedish pharmaceutical market has seen its growth stalled substantially over the last year as in 2007, the market had grown 6.8% y/y. In 2008, growth was hampered by low volume growth and lower overall pharmaceutical prices. Nonetheless, the market grew faster by value than by volume, illustrating a consumption shift towards more expensive medicines. With the ageing of the population, the demand for cancer treatments and immunomodulating agents is expected to increase, which will keep boosting the market by value.

Interestingly, sales of generic medicines and parallel imports have stalled by value. In 2007, value sales of generic medicines had grown by 11.6% y/y, well ahead of the overall market. However, by volume, sales of generics grew 7% y/y in 2008, illustrating the downward price pressure on generics and the use of increasingly cheaper alternatives. Generic substitution at the pharmacy level has been mandatory in Sweden since 2002 and the anticipated wave of patent expiry on blockbusters is expected to jump start the generic market again after the turn of the decade.

The government will find comfort in the fact that prices of pharmaceuticals for human use have fallen faster in 2008 than in 2007. The country is unlikely to make significant changes to its pricing and reimbursement environment in the short-term but rational use of medicines will remain high on the political agenda. Cost-effectiveness evaluation will remain the cost-containment measure of choice for innovative drugs while reimbursement reviews and generic promotion will contain expenditure on older drugs. The Dental and Pharmaceutical Benefits Agency (TLV) is currently reassessing the reimbursement status of 49 therapeutic groups and has already made changes to drugs licensed in the treatment of migraine, hypertension, depression, lipid disorders, excess stomach acid and respiratory diseases such as asthma, cough and chronic obstructive pulmonary disorder (COPD).
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