trending Market Intelligence /marketintelligence/en/news-insights/trending/uGI7jU3ABmwiMyDtWAD2lg2 content
Log in to other products

Login to Market Intelligence Platform


Looking for more?

Contact Us

Request a Demo

You're one step closer to unlocking our suite of comprehensive and robust tools.

Fill out the form so we can connect you to the right person.

If your company has a current subscription with S&P Global Market Intelligence, you can register as a new user for access to the platform(s) covered by your license at Market Intelligence platform or S&P Capital IQ.

  • First Name*
  • Last Name*
  • Business Email *
  • Phone *
  • Company Name *
  • City *
  • We generated a verification code for you

  • Enter verification Code here*

* Required

Thank you for your interest in S&P Global Market Intelligence! We noticed you've identified yourself as a student. Through existing partnerships with academic institutions around the globe, it's likely you already have access to our resources. Please contact your professors, library, or administrative staff to receive your student login.

At this time we are unable to offer free trials or product demonstrations directly to students. If you discover that our solutions are not available to you, we encourage you to advocate at your university for a best-in-class learning experience that will help you long after you've completed your degree. We apologize for any inconvenience this may cause.

In This List

Pfizer grants license to Axsome for research data on 2 drugs

COVID-19 Pandemic Likely To Cause US Telemedicine Boom

Gauging Supply Chain Risk In Volatile Times

S&P Global Market Intelligence

Cannabis: Hashing Out a Budding Industry


IFRS 9 Impairment How It Impacts Your Corporation And How We Can Help

Pfizer grants license to Axsome for research data on 2 drugs

Axsome Therapeutics Inc. entered into an agreement for an exclusive U.S. license to Pfizer Inc.'s clinical and nonclinical data, intellectual property for reboxetine, and the license to develop and market esreboxetine in the U.S.

New York-based Axsome is developing reboxetine, or AXS-12, for the treatment of narcolepsy. The sleep disorder is characterized by excessive sleepiness, sleep paralysis, hallucinations and episodes of cataplexy, or a partial or total loss of muscle control often triggered by a strong emotion such as laughter.

The drug significantly reduced the number of cataplexy attacks in patients in a mid-stage study and also holds orphan-drug status in the U.S. Pfizer markets reboxetine outside the U.S. for treating depression, but it is not approved in the U.S. for any indication.

Esreboxetine, or AXS-14, is being developed as a potential treatment of fibromyalgia — a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, and memory and mood issues. Under the agreement, Axsome will solely be responsible for developing AXS-14 for any indication.

Under the agreement, Pfizer will receive an up-front cash payment of $3 million, with up to $323 million in regulatory and sales milestones as well as mid-single to low double-digit royalties on future sales.

In addition, Pfizer will receive $8 million worth of Axsome's common stock and will have the right of first negotiation on any potential future strategic transactions involving the drugs.

Axsome will receive the license to Pfizer's data for AXS-12 and AXS-14, encompassing a full range of nonclinical studies, short-term and long-term clinical studies involving more than 5,000 patients. This includes results from a phase 2 and a phase 3 clinical trial of AXS-14 in the treatment of fibromyalgia in which the drug helped patients by significantly reducing pain.