trending Market Intelligence /marketintelligence/en/news-insights/trending/eT7ttTHtiTvpVN19iIz2Uw2 content
Log in to other products

Login to Market Intelligence Platform


Looking for more?

Contact Us

Request a Demo

You're one step closer to unlocking our suite of comprehensive and robust tools.

Fill out the form so we can connect you to the right person.

If your company has a current subscription with S&P Global Market Intelligence, you can register as a new user for access to the platform(s) covered by your license at Market Intelligence platform or S&P Capital IQ.

  • First Name*
  • Last Name*
  • Business Email *
  • Phone *
  • Company Name *
  • City *
  • We generated a verification code for you

  • Enter verification Code here*

* Required

In This List

Sarepta shares dive 13% after report of serious illness in gene therapy trial

Gauging Supply Chain Risk In Volatile Times

S&P Global Market Intelligence

Cannabis: Hashing Out a Budding Industry


IFRS 9 Impairment How It Impacts Your Corporation And How We Can Help

The Market Intelligence Platform

Sarepta shares dive 13% after report of serious illness in gene therapy trial

Shares of Sarepta Therapeutics Inc. fell almost 13% just after noon ET Aug. 8, the result of a report that its muscular dystrophy gene therapy caused an adverse reaction in a boy enrolled in a clinical study.

Cambridge, Mass.-based Sarepta is studying SRP-9001 in male patients ages 4 to 7 years old over 48 weeks, plus a 96-week extension study, according to the U.S. Food and Drug Administration's clinical trials database.

An incident submitted to the FDA's adverse event reporting system for approved therapies said the patient developed rhabdomyolysis, a serious illness associated with Duchenne muscular dystrophy. Rhabdomyolysis is a rare disease that causes rapid death of muscle tissue and can lead to kidney damage or failure.

Symptoms of the disorder showed up in the boy two weeks after infusion. He was hospitalized and discharged a day later.

Sarepta issued a release saying the report was erroneous and that none of its employees or study investigators had submitted the data. The study is double-blind, meaning neither patients nor Sarepta and study leaders know which treatments are being given to each individual. Neither side knows whether the boy had been taking the treatment or the placebo.

A safety monitoring board that is not blinded to the study has recommended the study continue.

Trading for Sarepta was halted around 12:30 p.m. ET and shares were down 6.52% to $132.98 at the end of the day.

Sarepta, which reported its second-quarter earnings a day earlier, had recently expanded the study's enrollees from 24 to 40 patients. CEO Doug Ingram said results should be ready by the end of 2020.