trending Market Intelligence /marketintelligence/en/news-insights/trending/5sCWx-CjlLUb1WnOYDXbcA2 content
Log in to other products

Login to Market Intelligence Platform


Looking for more?

Contact Us

Request a Demo

You're one step closer to unlocking our suite of comprehensive and robust tools.

Fill out the form so we can connect you to the right person.

If your company has a current subscription with S&P Global Market Intelligence, you can register as a new user for access to the platform(s) covered by your license at Market Intelligence platform or S&P Capital IQ.

  • First Name*
  • Last Name*
  • Business Email *
  • Phone *
  • Company Name *
  • City *
  • We generated a verification code for you

  • Enter verification Code here*

* Required

Thank you for your interest in S&P Global Market Intelligence! We noticed you've identified yourself as a student. Through existing partnerships with academic institutions around the globe, it's likely you already have access to our resources. Please contact your professors, library, or administrative staff to receive your student login.

At this time we are unable to offer free trials or product demonstrations directly to students. If you discover that our solutions are not available to you, we encourage you to advocate at your university for a best-in-class learning experience that will help you long after you've completed your degree. We apologize for any inconvenience this may cause.

In This List

Vertex prices drug combo therapy for cystic fibrosis at $311,503 annually

COVID-19 Pandemic Likely To Cause US Telemedicine Boom

Gauging Supply Chain Risk In Volatile Times

S&P Global Market Intelligence

Cannabis: Hashing Out a Budding Industry


IFRS 9 Impairment How It Impacts Your Corporation And How We Can Help

Vertex prices drug combo therapy for cystic fibrosis at $311,503 annually

Vertex Pharmaceuticals Inc. priced Trikafta — its triple combination treatment for a type of cystic fibrosis — at $311,503 annually, following the drug's U.S. approval, Reuters reported.

Cystic fibrosis is a rare, life-threatening inherited disorder characterized by buildup of mucus in the lungs and digestive system — causing severe damage to the affected organs. The disease is due to changes in the CFTR gene, with F508del mutation being the most common gene defect.

After a three-month review period, the U.S. Food and Drug Administration on Oct. 21 approved Trikafta, a combination of elexacaftor, tezacaftor and ivacaftor, for patients with cystic fibrosis aged 12 and older who have at least one F508del gene mutation. The group represents 90% of cystic fibrosis patients.

The approval was based on results from two studies that showed Trikafta improved lung function among patients. The first study tested the drug combination in 403 patients with one F508del mutation and one minimal function mutation for 24 weeks, while the second evaluated 107 patients with two identical F508del mutations.

Trikafta was granted a number of designations that provided for expedited review and certain development perks, including priority review, fast track, breakthrough and orphan drug.

Leerink analysts estimate the therapy to hit the shelves by the end of the first quarter of 2020. Leerink also estimates sales of Trikafta to grow to about $4.6 billion in 2023 and $6.6 billion by 2025.

Boston-based Vertex Pharmaceuticals markets ivacaftor as Kalydeco and the combination of tezacaftor and ivacaftor as Symdeko.

Trikafta is being further examined in a phase 3 clinical trial in younger patients, with a goal to earn an approval for patients aged six through 11.