trending Market Intelligence /marketintelligence/en/news-insights/trending/2jAN0lEHOBgoUvLy9QoDMw2 content
Log in to other products

Login to Market Intelligence Platform


Looking for more?

Contact Us

Request a Demo

You're one step closer to unlocking our suite of comprehensive and robust tools.

Fill out the form so we can connect you to the right person.

If your company has a current subscription with S&P Global Market Intelligence, you can register as a new user for access to the platform(s) covered by your license at Market Intelligence platform or S&P Capital IQ.

  • First Name*
  • Last Name*
  • Business Email *
  • Phone *
  • Company Name *
  • City *
  • We generated a verification code for you

  • Enter verification Code here*

* Required

Thank you for your interest in S&P Global Market Intelligence! We noticed you've identified yourself as a student. Through existing partnerships with academic institutions around the globe, it's likely you already have access to our resources. Please contact your professors, library, or administrative staff to receive your student login.

At this time we are unable to offer free trials or product demonstrations directly to students. If you discover that our solutions are not available to you, we encourage you to advocate at your university for a best-in-class learning experience that will help you long after you've completed your degree. We apologize for any inconvenience this may cause.

In This List

Scilex Holding's non-opioid steroid reduces chronic pain in phase 2 trial

COVID-19 Pandemic Likely To Cause US Telemedicine Boom

Gauging Supply Chain Risk In Volatile Times

S&P Global Market Intelligence

Cannabis: Hashing Out a Budding Industry


IFRS 9 Impairment How It Impacts Your Corporation And How We Can Help

Scilex Holding's non-opioid steroid reduces chronic pain in phase 2 trial

Sorrento Therapeutics Inc. subsidiary Scilex Holding Co.'s non-opioid gel injection for a type of spinal pain reduced daily leg and back pain, according to the newly formed company's phase 2 trial results.

The corticosteroid injection for sciatica, called SP102, was tested in 19 patients enrolled in the trial, Scilex Holding's March 26 press release said. SP102 was administered via epidural injection, around the spinal cord, and 15 out of the 19 patients received repeat injections four to eight weeks after the index injection.

After the repeat injections, all 15 patients experienced a reduction in pain as measured by the Numeric Pain Rating Scale, and the current and worst pain in patients' affected leg was "mostly" reduced by over 50% for each injection in the 28-day period.

California-based Scilex Holding said all injections were well-tolerated, with no serious adverse events reported. In addition, no differences were detected between the first and second injections. Cortisol suppression time lasted up to five days and was similar for the two injection treatments, Scilex Holding said.

Currently, there are no U.S. Food and Drug Administration-approved treatments of this kind for sciatica.

SP102 is also slated for a phase 3 trial, Scilex Holding stated.

Sciatica, or lumbar radiculopathy, is caused by compression or irritation of nerve roots in the lower back and creates radiating pain down the buttocks, or one or both legs. The chronic pain condition affects more than 30 million Americans, according to Scilex Holding, and about 10 million to 11 million off-label epidural steroid injections are administered each year in the U.S. to address sciatica.